The discovery and utilization of RNA-guided surveillance complexes,such as CRISPR-Cas9,for sequencespecific DNA or RNA cleavage,has revolutionised the process o
Genetically engineered mouse(GEM)models are commonly used in biomedical research.Generating GEMs involve complex set of experimental procedures requiring sophis
Genome editing has undergone rapid development in recent years,yielding new approaches to make precise changes in genes.In this review,we discuss the developmen