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异搏停和地高辛同时服用可引起地高辛血浆浓度的增高并未引起广泛的重视。作者报告2例严重心脏病患者,在服用地高辛的基础上附加异搏停治疗以控制快速心率,由于血浆地高辛浓度均明显升高而导致患者死亡。 1例为前侧壁心肌梗塞、心房纤颤、心脏扩大伴心力衰竭,服用地高辛每日0.25mg维持治疗。加用异搏停80mg每日2次,2天后地高辛浓度达1.4ng/ml;
Verapamil and digoxin at the same time can cause elevated digoxin plasma concentrations did not cause widespread attention. The authors report two patients with severe heart disease, taking digoxin treatment based on the addition of verapamil to control rapid heart rate, due to plasma digoxin concentrations were significantly increased and led to the death of patients. 1 case of anterior wall myocardial infarction, atrial fibrillation, heart enlargement with heart failure, taking digoxin daily 0.25mg maintenance treatment. Plus verapamil 80mg twice daily, 2 days after digoxin concentration of 1.4ng / ml;