论文部分内容阅读
目的探讨骨代谢标志物Ⅰ型前胶原氨基端延长肽(P1NP)、β胶原特殊序列(β-Crosslaps)与维持性血透(MHD)患者全段甲状旁腺激素(iPTH)水平的相关性。方法化学发光法检测96例MHD患者iPTH水平,并以此分为高iPTH水平组(>300ng/L,A组,40例),中iPTH水平组(150～300ng/L,B组,26例)和低iPTH水平组(<150ng/L,C组,30例)。同时测定各组P1NP和β-Crosslaps水平。结果 A组P1NP和β-Crosslaps水平明显高于B、C组(P<0.05)。P1NP、β-Crosslaps与iPTH均呈明显正相关。结论 MHD患者血清P1NP、β-Crosslaps水平与肾性骨病(RBD)存在密切的相关性,可作为RBD早期诊断的指标。
Objective To investigate the correlation between the level of iPTH in the patients with maintenance of hemodialysis (MHD) and the type Ⅰ procollagen markers of bone metabolism (P1NP), β-Crosslaps. Methods The levels of iPTH in 96 patients with MHD were detected by chemiluminescence method and divided into high iPTH group (> 300ng / L, A group, 40 cases), iPTH group (150-300ng / L, B group, 26 cases ) And low iPTH group (<150ng / L, C group, 30 cases). The levels of P1NP and β-Crosslaps in each group were also determined. Results The levels of P1NP and β-Crosslaps in group A were significantly higher than those in groups B and C (P <0.05). P1NP, β-Crosslaps and iPTH showed a significant positive correlation. Conclusion The serum levels of P1NP and β-Crosslaps in patients with MHD are closely related to RBD and can be used as an index for early diagnosis of RBD.