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目的:优选甘草制款冬花的炮制减毒工艺,为款冬花的炮制生产工艺提供参考。方法:以总生物碱含量为指标,甘草水煎煮次数、烘制温度及甘草用量(甘草质量/款冬花质量)为考察因素,采用正交试验对甘草制款冬花的减毒工艺进行优选,考察款冬花甘草制品中有效成分含量的变化。结果:款冬花甘草制最佳减毒工艺条件为甘草用量10%,水煎煮数3次,烘制温度90℃;甘草制款冬花中总生物碱、款冬酮及醇浸出物质量分数分别为0.080 3 mg·g-1,0.161%,26.31%。结论:与生品相比,款冬花甘草制品中总生物碱含量显著减少,款冬酮和醇浸出物含量增加。优选的款冬花甘草制减毒工艺稳定可行,提示甘草汁制款冬花有一定的合理性,具有实际应用意义。
Objective: To optimize the process of licorice coltsfoot processing of attenuated, processing for the coltsfoot flower processing technology to provide a reference. Methods: The total alkaloids content as an indicator, the number of boiling water of licorice, baking temperature and the amount of licorice (liquorice quality / quality of coltsfoot flower) were investigated. The orthogonal experiment was used to optimize the process of attenuating the liquorice, To investigate the changes in the content of active ingredients in the product of Coltsfoot Flower. Results: The optimal dosage of licorice root was glycyrrhiza glabra 10%, water boiling 3 times and baking temperature 90 ℃. The content of total alkaloids, 0.080 3 mg · g -1, 1.61 1%, 26.31%. CONCLUSION: Compared with the raw product, the content of total alkaloids in the product of Colletotrichum was significantly reduced, and the content of the calcein and alcohol extract increased. The optimal coltsfoot glycyrrhizae attenuating process is stable and feasible, suggesting that there is a certain degree of rationality in the winter flower of licorice juice system, which has practical significance.