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淀粉样沉积症是致命性的疾病,可以是神经退行性的,也可以是系统性的.该疾病以错误折叠蛋白质的堆积、缠绕成纤维为特征,最终导致受累组织、器官的渐进性坏死.目前,没有有效的治疗手段可以阻止该类疾病的进程.错误折叠蛋白质的累积诱导内质网应激,被认为是退行性疾病的标志.血管生成素不仅可以调节细胞生长和增殖,也在应激条件下细胞存活中发挥作用.最近,发现血管生成素介导的应激反应可以减轻蛋白聚积造成的损伤,提示该蛋白可能在退行性疾病中具有新功能.本综述概述了血管生成素在淀粉样沉积症中的研究进展,特别是描述了血管生成素失调与该类疾病的起始和进展间的关系.我们认为,深入了解血管生成素失调的分子基础有助于发展与蛋白质错误折叠和聚积相关的退行性疾病的治疗方法.
Amyloidosis is a fatal disease that can be either neurodegenerative or systemic The disease is characterized by the accumulation of misfolded proteins, wound into fibers, and ultimately the progressive necrosis of affected tissues and organs. At present, there is no effective treatment to prevent the progression of these diseases.Cumulative folding of misfolded proteins induces endoplasmic reticulum stress, which is considered as a sign of degenerative diseases.Angiogenin can not only regulate cell growth and proliferation, Stimulated cell survival recently Recently found that angiogenin-mediated stress response can reduce the damage caused by protein accumulation, suggesting that the protein may have a new function in degenerative diseases This review summarizes the role of angiogenin in The progress in the study of amyloidosis, in particular, describes the relationship between the angiogenin imbalance and the onset and progression of such diseases, and we believe that a deeper understanding of the molecular basis of angiogenin disorders can contribute to the development of misfolded proteins And accumulation of related degenerative diseases treatment.