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目的了解蒿甲醚和青蒿琥酯对小鼠曼氏血吸虫作用的效果。方法将小鼠随机分成12个实验组及1个对照组,以皮下注射的方法,每鼠接种约80条尾蚴,接种尾蚴46d后,分别以蒿甲醚或青蒿琥酯灌胃治疗,第1天,分别以400、300、200mg/kg的剂量1次灌胃;第2～7天,则每天分别按以上剂量的半量灌胃,7d灌胃的总剂量分别为1600、1200、800mg/kg。总量1剂组,在第7天,分别按1600、1200、800mg/kg剂量1次灌胃。另设感染阳性对照组,不加治疗。结果蒿甲醚7日疗法1600、1200、800mg/kg剂量组减虫率分别为53.0%、49.0%和53.0%,减雌率为78.0%～82.0%,总量1剂组效果与7日疗法基本相同。青蒿琥酯7日疗法相应剂量减虫率分别为16.0%、37.0%和49.0%。结论蒿甲醚和青蒿琥酯对小鼠曼氏血吸虫具有一定的杀虫效果,蒿甲醚在疗效和毒性方面稍佳。
Objective To understand the effect of artemether and artesunate on Schistosoma mansoni in mice. Methods The mice were randomly divided into 12 experimental groups and 1 control group. Each mouse was inoculated with about 80 cercariae by subcutaneous injection. After inoculation of cercariae for 46 days, mice were treated with artemether or artesunate separately. 1 day, respectively, 400,300,200mg / kg dose of 1 gavage; 2 to 7 days, respectively, according to the above dose of half a day, the total dose of 7d gavage were 1600,1200,800 mg / kg. The total amount of 1 dose group, on the 7th day, respectively, by 1600,1200,800mg / kg dose of 1 gavage. Another infection-positive control group, without treatment. Results Artemether 7th treatment 1600,1200,800mg / kg dose group worm reduction rates were 53.0%, 49.0% and 53.0%, the reduction rate of 78.0% to 82.0%, the total amount of 1 dose group and 7-day treatment basically the same. Artesunate on the 7th dose of the corresponding dose of worm reduction were 16.0%, 37.0% and 49.0%. Conclusion Artemether and artesunate have certain insecticidal effect on Schistosoma mansoni. Artemether is slightly better in efficacy and toxicity.