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可溶性人类白细胞抗原（ｓＨＬＡ）是存在于人类血清中ＨＬＡ的可溶性形式。近几年来，人们对ｓＨＬＡ进行了大量的研究，发现ｓＨＬＡ与器官移植中的移植物抗宿主反应（ＧＶＨＲ）和移植器官的排斥有密切的关系。在某些自身免疫性疾病和感染性疾病中，血清中的ｓＨＬＡ变化也很大。本文就近几年人们对ｓＨＬＡ进行的研究予以了综述。
Soluble human leukocyte antigen (sHLA) is a soluble form of HLA present in human serum. In recent years, a large number of studies have been conducted on sHLA and found that sHLA is closely related to graft versus host reaction (GVHR) in organ transplantation and rejection of transplanted organs. In some autoimmune and infectious diseases, there is also a significant change in serum sHLA. In this paper, the recent research on sHLA has been reviewed.