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高能饮食诱发胆固醇结石一般认为是由于胆固醇直按摄入或脂肪及糖在肝内的转化增多,增加了胆汁胆固醇的分泌,使其过饱和成为结石形成原因之一。月见草油主要有效成分是γ-亚麻酸,具有纠正脂质代谢紊乱,降低血糖等药理作用。我们通过动物实验以观察月见草油预防胆固醇结石的作用并探讨其机理。1 1%#11材料与方法豚鼠48只,雌雄各半,体重300~500g/只(由解放军兽医大学实验动物中心提供),随机分为3组。致石组饲正常饲料加20%葡萄糖粉及1.5%胆固醇粉(北京化工厂产品);实验组饲致石饮食加月见草油2ml/(kg·d)(白求恩医科大学制药厂产品);对照组
High-energy diet-induced cholesterol stones are generally considered to be due to direct cholesterol intake or fat and sugar conversion in the liver increased, increased bile cholesterol secretion, making it one of the reasons for the formation of stones. The main active ingredient of evening primrose oil is γ-linolenic acid, with the correct lipid metabolism disorders, lower blood sugar and other pharmacological effects. We through animal experiments to observe the evening primrose oil prevention of cholesterol stones and explore its mechanism. 1 1% # 11 Materials and methods 48 guinea pigs, male and female, weight 300 ~ 500g / only (provided by the Experimental Animal Center of PLA Veterinary University) were randomly divided into three groups. The rats in Zhishi group were fed with normal diet supplemented with 20% glucose powder and 1.5% cholesterol powder (products of Beijing Chemical Plant). The experimental group was fed with 2ml / (kg · d) of evening primrose oil diet (Bethune Medical University Pharmaceutical Factory) Control group