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目的探讨临床对大脑中动脉狭窄脑梗死患者联用氯吡格雷与阿司匹林治疗的可行性。方法将2012年5月至2014年5月我院收录并治疗的56例大脑中动脉狭窄脑梗死患者纳入研究,随机将患者等分成2组,对照组予以单纯阿司匹林口服,观察组增加氯吡格雷用药,研究2组的治疗效果。结果治疗前,2组的Barthel指数评分与Fugl-Meyer评分对比相仿(P>0.05);经治疗后均出现改善,且以观察组改善更明显(P<0.05)。相比对照组,观察组的复发率与进展率均更低(P<0.05)。结论:对大脑中动脉狭窄脑梗死患者联用氯吡格雷与阿司匹林治疗,疗效更显著,且可有效控制病情进展与复发,适合加强普及。
Objective To investigate the clinical feasibility of combining clopidogrel with aspirin in patients with cerebral infarction of middle cerebral artery. Methods Fifty-six patients with middle cerebral artery stenosis and cerebral infarction admitted and treated in our hospital from May 2012 to May 2014 were enrolled in the study. Patients were randomly divided into two groups. The control group was treated with aspirin alone. The observation group was given clopidogrel Medication, study the treatment effect of 2 groups. Results Before treatment, the Barthel index scores of two groups were similar to those of Fugl-Meyer score (P> 0.05). Both of them improved after treatment and were more obvious in the observation group (P <0.05). Compared with the control group, the observation group’s recurrence rate and progression rate were lower (P <0.05). Conclusion: The treatment of middle cerebral artery stenosis with cerebral infarction combined with clopidogrel and aspirin, the effect is more significant, and can effectively control the disease progression and recurrence, suitable for strengthening the popularization.