专家点评:不少临床医师缺乏系统的药物治疗学培训,因此用药的效果受到限制。这篇涉及耐药革兰阴性菌感染抗菌治疗的药效学译文,介绍了科学选药的思路,以及针对时间依赖型或浓度依赖型抗菌药,确定用药剂量和次数等原则,对合理用药提供实用价值很大的资料,值得一读。当今,各医疗机构正在认真实施卫生部《抗菌药物临床应用指导原则》和上海市卫生局颁布的实施细则,临床药师应抓住良机,深入临床一线,将这些知识带给临床医师,会同临床微生物领域的同道,相互学习,相互配合,把医院合理应用抗菌药的水平扎扎实实地提高一步。复旦大学附属华山医院传染病科抗生素研究所资深教授卫生部《抗菌药物临床应用监测中心》顾问专家张永信 Expert Comments: Many clinicians lack of systematic training in drug therapy, so the effect of medication is limited. This article addresses the pharmacodynamic translation of antimicrobial therapy of drug-resistant Gram-negative bacteria. It introduces the scientific concept of drug selection, as well as the principles of time-dependent or concentration-dependent antimicrobial agents, the determination of dose and frequency of drug administration, and rational drug use Practical information of great value, it is worth reading. Today, the medical institutions are earnestly implementing the “Guiding Principles for Antibacterials Clinical Application” issued by the Ministry of Health and the implementation rules promulgated by the Shanghai Municipal Health Bureau. Clinical pharmacists should seize the opportunity to go deep into the clinical front line, bringing these knowledge to clinicians and clinical micro-organisms Field of fellow, learn from each other, cooperate with each other, the level of rational use of anti-bacterial drugs hospital to step up step by step. Fudan University, Huashan Hospital, Department of Infectious Diseases, Senior Professor of Antibiotics, Ministry of Health, “Clinical Application of Antibacterial Drug Monitoring Center,” an expert consultant Zhang Yongxin