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目的 :为了解接触焦炉逸散物职业性人群遗传效应的改变 ,从分子水平揭示焦炉逸散物的遗传毒作用。方法 :对 2 5名焦炉工和 12名正常对照分别检测了血清P2 1和外周血淋巴细胞姐妹染色单体互换 (SCE)率。结果 :发现焦炉工P2 1水平 (3774.2 )、SCE率 (11.43)明显高于对照组P2 1水平 (12 70 .7)和SCE率 (6 .37) ;焦炉工中 ,炉顶工血清P2 1均值 (4377.5 )高于其它工种 (330 0 .1) ,炉顶工SCE(13.5 1)明显高于其它工种 (10 .0 7) ;对焦炉工按是否吸烟进行比较 ,未发现组间P2 1和SCE有差异显著性。结论 :提示焦炉逸散物具有较强的遗传毒理学效应 ,可提高机体癌蛋白P2 1水平和SCE频率。
OBJECTIVE: To understand the genetic effect of occupational exposure to coke oven fugitives and to reveal the genetic toxic effects of coke oven fugitives at the molecular level. Methods: Sister chromatid exchange (SCE) rates of serum P2 1 and peripheral blood lymphocytes were detected in 25 coke oven workers and 12 normal controls respectively. Results: The coke oven workers found that P2 1 level (3774.2) and SCE rate (11.43) were significantly higher than P2 1 level (12 70.7) and SCE rate (6.67) The mean value of P2 1 (4377.5) was higher than that of other types of work (330 0 .1). The SCE (13.5 1) of top workers was significantly higher than that of other types of work (10 .0 7) There was a significant difference between P2 1 and SCE. Conclusion: It suggests that coke oven discharge has a strong genotoxic effect, which can increase the level of oncoprotein P2 1 and SCE frequency.