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采用体内和体外测定方法,比较研究了甘草酸(18β-GL)和甘草次酸(18β-GA)的抗肝毒活性。在D-半乳糖胺处理前1,24和48h,对大鼠经口投与18β-GA.在D-半乳糖胺给药后24h,18β-GA可明显减少血清转氨酶活性的增加,但18β-GL未能抑制血清转氨酶活性的增加。D-半乳糖胺处理前1h,腹腔注射18β-GA,可恢复血清转氨酶活性的增加。在四氯化碳诱导初级培养大鼠肝细胞的毒性中,在5～50μg/ml剂量时,18β-GA保护四氯化碳诱导的转氨酶渗漏。但
The in vivo and in vitro assays were used to compare the anti-hepatic activity of glycyrrhizic acid (18β-GL) and glycyrrhetinic acid (18β-GA). Rats were administered orally with 18β-GA at 1, 24, and 48 h before D-galactosamine treatment. 18β-GA significantly decreased the serum transaminase activity 24 h after D-galactosamine administration, but 18 β- GL failed to inhibit the increase of serum transaminase activity. One hour before D-galactosamine treatment, intraperitoneal injection of 18β-GA restored serum transaminase activity. In the toxicity of carbon tetrachloride-induced primary cultured rat hepatocytes, 18β-GA protected carbon tetrachloride-induced transaminase leakage at a dose of 5-50 μg/ml. but