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实验动物为雄豚鼠。将空腹豚鼠用戊巴比妥(35mg/kg)麻醉,腹壁切口,将胃两端结扎。向胃内注入溶于0.25ml(生理盐水的250微克N-二甲基亚硝胺(NDMA),同样向已结扎的小肠内注入NDMA。在2.5～20分钟内每隔一定时间,取胃和小肠,测定其内容物中NDMA含量。胃和小肠都可吸收,但从胃中清除要比小肠慢的多。如2.5分钟胃残存92.5％,小肠为67.1％;15分钟分别为55.3％及7.0％;20分钟胃残有46.8％,而小肠只有2.2％。
Experimental animals male guinea pigs. Fasting guinea pigs were anesthetized with pentobarbitone (35 mg / kg), incised in the abdominal wall, and both ends of the stomach were ligated. Into the stomach was dissolved in 0.25ml (saline 250 micrograms N-dimethylnitrosamine (NDMA), was also injected into the ligation of the small intestine NDMA.At constant time within 2.5 to 20 minutes, take the stomach and Small intestine, the contents of NDMA content determination of the stomach and small intestine can be absorbed, but from the stomach to clear more slowly than the small intestine, such as 2.5 minutes gastric residual 92.5%, small intestine 67.1%; 15 minutes were 55.3% and 7.0 %; Gastric residue in 20 minutes 46.8%, while only 2.2% of the small intestine.