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阴茎癌占美国癌症死亡的1%,在锡兰占30%,在乌干达占70%。手术和放疗可以治愈恶性程度低及早期病例,但有转移者疗效不佳。顺铂治疗膀胱、头颈、食管和肺的表皮癌是有效的。本文作者用顺铂治疗活检证实的Jackson Ⅲ、Ⅳ期阴茎表皮癌27例。用法为:顺铂50mg/m~2溶于葡萄糖生理盐水,在1～4小时内静脉注射,每个疗程28天,于疗程的第1,8天用药。一个疗程后根据白细胞、血小板、肌酐清除率情况调整用药剂量。能够评价疗效和毒性的有26例。其中4例显示部分缓解,无完全缓解者有效率为15.4%。缓解时间为1～3个月。显效部位为
Penile cancer accounts for 1% of cancer deaths in the United States, 30% in Ceylon and 70% in Uganda. Surgery and radiotherapy can cure low malignancy and early cases, but metastases are ineffective. Cisplatin is effective in the treatment of epidermal cancers of the bladder, head and neck, esophagus and lungs. The authors used cisplatin to treat 27 cases of stage III and IV penile epithelial carcinoma confirmed by biopsy. Usage: Cisplatin 50mg/m~2 soluble in glucose saline, intravenous injection within 1 to 4 hours, each course of 28 days, on the first and 8 days of treatment medication. After one course of treatment, the dosage was adjusted according to the leukocyte, platelet, creatinine clearance rate. There were 26 cases that could evaluate efficacy and toxicity. Of these, 4 showed partial remission, and those without complete remission were 15.4%. Remission time is 1 to 3 months. The effective part is