【摘 要】
：
泛素化和SUMO化是蛋白质翻译后修饰的重要方式,广泛参与调节蛋白质功能和细胞生命活动各个环节.多聚泛素化降解蛋白质,而SUMO化主要调节蛋白质的相互作用和定位等.在不同情况
论文部分内容阅读
泛素化和SUMO化是蛋白质翻译后修饰的重要方式,广泛参与调节蛋白质功能和细胞生命活动各个环节.多聚泛素化降解蛋白质,而SUMO化主要调节蛋白质的相互作用和定位等.在不同情况下,SUMO化和泛素化既可协同调节蛋白质功能,也可相互拮抗. 最近研究发现,某些底物的SUMO化能够激活体内一类新发现的SUMO依赖的泛素连接酶,启动泛素-蛋白酶体途径降解底物, 导致蛋白质SUMO化和泛素化的关系进一步精细化和复杂化.
其他文献
The impact of land-use on distributed groundwater recharge and discharge in the western Jilin (WJ) was analyzed in this study. WJ is a transitional, semi-arid zone with a fragile, hydrological closed
One mutant line eto with salt tolerance was screened from a T-DNA insertion mutant collection of Arabidopsis thaliana. In addition to a reduced rate of seed ger
This paper presents a new designed miniature six DOF (degree of freedom) force/torque sensor.This sensor is fully integrated with a micro DSP (digital signal pr
By using Normalized Difference Vegetation Index (NDVI) with the resolution of 80km(80km, satellite remote sensing data, derived from the National Oceanic and At
A new low-molecular-weight peptide with phenol oxidase activity, named Pc factor, was isolated and purified from liquid culture of a white-rot basidiomycete Pha
In CNC machining, two essential components decide the accuracy and machining time for a sculptured surface: one is the step-size interval, the other is the tool
目的 筛选四环素诱导细胞周期素B1(Cyclin B1)可控表达的293单克隆细胞株(tetracycline-regulated expression 293 cells,T-RExTM-293).方法 从人胎肝cDNA文库中PCR带有酶切
20世纪末以来,我国推出了一系列区域经济发展政策,经过十多年的发展,我国大部分地区的经济开放程度有所提升,区际贸易得到发展,尤其是东西部地区的经济联系得到加强.但是,东
保障房的准入问题一直备受关注,虽然各地制定了严格的申请标准和审核制度,但由于一些申请者不能如实反映真实情况以及审核部门不能严格把关,致使骗租骗购现象屡见不鲜。本文
相比.治疗组犬在心率、血常规、血清总蛋白和血清白蛋白、电解质含量、凝血酶原时间、部分活化凝血酶原时间、血清补体C3浓度及纤维蛋白酶含量等生理指标,均未见显著性差异(P