目的 :探讨酸味中药复方对糖尿病大鼠肾小球病变的影响。方法 :应用免疫组织化学和图像分析法检测了肾小球内高级糖化产物、血小板源生长因子 A以及毛细血管基膜与系膜区的结果变化。结果 :糖尿病大鼠肾小球终末糖化产物增加 ,肾小球血小板源生长因子 A明显增高 ,肾小球发生基膜增厚和系膜增宽的病理变化。结论 :酸味中药复方对糖尿病大鼠肾的非酶糖化反应和血管病变有一定的抑制作用。 Objective: To investigate the effect of sour traditional Chinese medicine on glomerular lesions in diabetic rats. Methods: Immunohistochemistry and image analysis were used to detect the changes of high glomerular glycation products, platelet-derived growth factor A, capillary basement membrane and mesangial area. Results: Glomerular terminal glycation products increased, glomerular platelet derived growth factor A was significantly increased, glomerular basement membrane thickening and mesangial widening pathological changes. Conclusion: Sour Chinese herbal compound can inhibit non-enzymatic glycation and vascular lesions of kidney in diabetic rats.