病人,女,32岁。因右乳腺癌根治术后化疗(采用CMF方案)1次静推氨甲喋呤500mg/20ml,即刻引起严重恶心,频繁呕吐,畏食,头痛,眩晕,心悸,不安。2d后面颈头部出现片状散在瘀斑;口唇肿胀明显,手、足、掌片状水泡;口腔粘膜糜烂,剥脱,溃疡,全身毛发脱落。剧痛、流涎不止,吞咽,发音十分困难。第6天出现持续弥漫性腹痛,腹泻,严重时3～5次/h粘液血便。化 Patient, female, 32 years old. Methotrexate 500mg / 20ml once a day due to chemotherapy after radical mastectomy (using CMF regimen) immediately causes severe nausea, frequent vomiting, vomiting, headache, dizziness, palpitations and anxiety. 2d behind the neck appeared patchy scattered ecchymosis; lips swollen obviously, hands, feet, palpebral blisters; oral mucosal erosion, exfoliation, ulcers, body hair loss. Severe pain, drooling, swallowing, pronunciation is very difficult. On the 6th day of continuous diffuse abdominal pain, diarrhea, severe 3 to 5 times / h mucus bloody stool. The