1956年从福州土壤中首先分离得到的抗癌抗生素——放线菌素23-21是一多组分混合物(主要为组分Ⅲ和Ⅳ)[1、2],对小鼠艾氏腹水癌的疗效最显著[3—5],剂量合适可使小鼠存活时间延长高达175.0％。而对小鼠S_(180)、U_(14)疗效不明显,对615小鼠白血病无效[5]。本药曾名更新霉素,近年产品名为新福菌素(Sinoactinomycin),曾在临床治疗恶葡和绒癌90例,采用缓慢静脉滴注,每日300～400mcg,显效(?)6.2％,有效8.6％,无效5.2％(8)。另对淋巴瘤、 In 1956, the first antitumor antibiotic-actinomycin 23-21 isolated from the soils of Fuzhou was a multi-component mixture (mainly components III and IV) [1,2] The most significant effect [3-5], the appropriate dose of mice can extend the survival time up to 175.0%. The mice S_ (180), U_ (14) curative effect is not obvious, 615 mice leukemia is invalid [5]. The drug was renamed neomycin, in recent years the product name is neophenrin (Sinoactinomycin), has been in the treatment of 90 cases of malignant and choriocarcinoma, the use of slow intravenous infusion of 300 ~ 400mcg daily, markedly (?) 6.2% , Effective 8.6%, invalid 5.2% (8). Another for lymphoma,