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目的:观察苯那普利联合银杏达莫注射液对糖尿病肾病(DN)患者蛋白尿、肾功能以及血液流变学指标的影响。方法:75例2型糖尿病肾病患者随机分为对照组和治疗组,对照组给予饮食控制、降糖、降脂等常规治疗,对照组在常规治疗基础上给与苯那普利和银杏达莫注射液治疗,疗程共12周,分别观察治疗前后两组患者空腹血糖、血脂和肾功能以及UAER和血液流变学参数的变化。结果:治疗12周后,两组患者空腹血糖控制良好,治疗组患者UAER较对照组明显下降,分别为314.62±49.83 mL/min和282.97±36.62 mL/min,治疗组患者肾功能和血液流变学参数较治疗前明显改善(P<0.05)。结论:苯那普利联合银杏达莫注射液能明显改善糖尿病肾病患者血液流变学参数,提高肾脏功能,减少24 h尿蛋白。
Objective: To observe the effects of benazepril combined with ginkgo dipyridolum injection on proteinuria, renal function and hemorheology in patients with diabetic nephropathy (DN). Methods: A total of 75 patients with type 2 diabetic nephropathy were randomly divided into control group and treatment group. The control group was given conventional therapy such as diet control, hypoglycemic and lipid-lowering. The control group was given benazepril and gingko-damo injection Liquid treatment, a total of 12 weeks treatment were observed before and after treatment in patients with fasting blood glucose, blood lipid and renal function, and UAER and blood rheology parameters. Results: After 12 weeks of treatment, the fasting blood glucose was well controlled in both groups. The UAER in the treatment group was significantly lower than that in the control group (314.62 ± 49.83 mL / min and 282.97 ± 36.62 mL / min, respectively). The renal function and blood rheology The learning parameters were significantly improved compared with those before treatment (P <0.05). Conclusion: Benazepril combined with Ginkgo biloba injection can significantly improve hemorrheological parameters, improve renal function and reduce 24 h urinary protein in patients with diabetic nephropathy.