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目的观察喜炎平注射液对人鼻病毒致小鼠感染的抗病毒作用。方法采用人鼻病毒感染小鼠作为模型,测定不同浓度喜炎平注射液对感染小鼠病死率及平均生活日的影响;测定其对感染小鼠气管—肺脏匀浆中的病毒滴度的影响,观察其抗病毒的能力。结果在观察的时间内,喜炎平注射液中剂量组与模型组比较,可显著减少病死率;与模型组相比,喜炎平可显著延长动物平均生存时间;喜炎平不同剂量组对病毒感染小鼠的肺脏病变均有不同程度的改善作用;喜炎平注射液可明显降低气管—肺脏组织匀浆中病毒滴度。结论喜炎平注射液具有抗人鼻病毒的治疗作用,在体内可有效抑制人鼻病毒增殖,能减轻受试动物呼吸道病变,提高存活率,不良反应很低,为进一步临床推广应用提供了实验依据。
Objective To observe the anti-virus effect of Xiyanping injection on mice infected by human rhinovirus. Methods Human rhinovirus-infected mice were used as model to determine the effect of different concentrations of Xiyanping injection on the mortality and average life of infected mice. The effects of Xiyanping Injection on virus titer in tracheal-lung homogenates were determined , Observe its anti-virus ability. Results During the observation period, Xiyanping injection dose group compared with the model group can significantly reduce the mortality; compared with the model group, Xiyanping significantly prolong the average survival time of animals; Xiyanping different doses of the group Infection of mice with lung lesions have varying degrees of improvement; Xiyanping injection can significantly reduce tracheal-lung tissue homogenates of virus titer. Conclusion Xiyanping injection has the anti-human rhinovirus therapeutic effect in the body can effectively inhibit the proliferation of human rhinovirus, can reduce the animal’s respiratory tract disease, improve survival, adverse reactions are low, for further clinical application of the experiment provided in accordance with.