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25例嗜铬细胞瘤(PCCT)所致心血管病变,10例诊断为儿茶酚胺心肌病,8例出现左心衰,2例发生心肌梗死。这是PCCT严重并发症,早期极易误诊为原发性高血压。67%的患者有ECG异常。17例经手术治疗后血压及心功能基本恢复正常,ECG大多数于根治术后1~8周正常,所以PCCT所致高血压属于一种可治愈的继发性高血压。但要警惕该病起病急,经过凶险,常因突然发作使病情恶化,甚至死亡。故强调,早期诊断、切除肿瘤为最根本治疗方法。哌唑嗪可做为PCCT诊断性试验药物之一,可做为术前用药,联合使用α、β受体阻断剂是术前治疗PCCT的较理想药物
In 25 cases of cardiovascular disease caused by pheochromocytoma (PCCT), 10 cases were diagnosed as catecholamine cardiomyopathy, 8 cases had left heart failure, and 2 cases had myocardial infarction. This is a serious complication of PCCT, and it is easily misdiagnosed as primary hypertension early. 67% of patients had abnormal ECG. In 17 cases, blood pressure and cardiac function returned to normal after surgical treatment. Most ECGs were normal 1-8 weeks after radical surgery. Therefore, PCCT-induced hypertension is a curable secondary hypertension. However, we must be alert to the acute onset of the disease. After a dangerous accident, we often make the condition worse and even die due to a sudden attack. It is emphasized that early diagnosis and removal of tumors are the most fundamental treatment methods. Prazosin can be used as one of the PCCT diagnostic test drugs. It can be used as a preoperative drug. The combination of alpha and beta receptor blockers is an ideal drug for preoperative treatment of PCCT.