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目的：从内分泌因素的角度对胎儿生长发育及其异常进行研究，以探讨ＩＵＧＲ与脐血中表皮生长因子（ＥＧＦ）水平的关系。方法：选择伴有ＩＵＧＲ的孕妇２２例及正常孕妇３８例，于分娩时抽取脐血，用放射免疫测定法（ＲＩＡ）测定ＥＧＦ水平，同时测定胎儿体重与胎盘重量，比较两组的差异。结果：正常体重儿（３４０９．１±２８４．７９ｇ）组的脐血ＥＧＦ水平（６２４．６４±７３．９０μｇ／Ｌ）明显高于低体重儿（２４０３．３±２７７．４１ｇ）组（２１７．９０±５４．５２μｇ／Ｌ）（Ｐ＜０．０５）；ＩＵＧＲ组胎盘重量３５４．３±９２．６４ｇ亦明显低于正常组的５４２．１±７８．３２ｇ（Ｐ＜０．０１）。结论：脐血中低ＥＧＦ水平是ＩＵＧＲ的相关因素之一，对妊娠过程中ＥＧＦ的作用及其机制进行研究有助于探讨ＩＵＧＲ病因及临床治疗。
OBJECTIVE: To study the relationship between IUGR and epidermal growth factor (EGF) level in cord blood from the perspective of endocrine factors. Methods: 22 pregnant women with IUGR and 38 normal pregnant women were selected. Umbilical cord blood was collected during delivery and EGF level was measured by radioimmunoassay (RIA). The body weight and placental weight were measured at the same time. The differences between the two groups were compared. Results: The level of EGF in cord blood of normal weight group (3409.1 ± 284.79g) was significantly higher than that of low weight group (624.64 ± 73.90μg / L) (2403.3 ± 277.41g) (217. 90 ± 54.52μg / L) (P <0.05). The placental weight of 354.3 ± 92.64g in IUGR group was significantly lower than that in normal group (542.1 ± 78.32g, P <0.01). CONCLUSION: Low EGF levels in umbilical cord blood are one of the related factors of IUGR. The study on the role and mechanism of EGF during pregnancy may be helpful to explore the etiology and clinical treatment of IUGR.