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目的研究及淋巴细胞存活与成熟必须因子(BAFF)、多药耐药相关基因(MRP)和程序死亡蛋白1的2配体(PD-L2)在大肠癌中的表达及其意义。方法应用免疫组化S-P法及检测大肠癌组织60例,大肠正常组织10例,观察BAFF、MRP和PD-L2在大肠癌中的表达及其与临床指标的关系。结果(1)60例大肠癌组织中,BAFF、MRP和PD-L2的表达阳性检出率分别为:83.3%(50/60)、41.7%(25/61)和68.9%(42/61)。而在大肠正常组织中,BAFF、MRP、PD-L2的表达阳性检出率分别为:20%(1/10)、0%(0/10)、0%(0/10)。(2)临床症状与BAFF、MRP、PD-L2的表达与临床症状有关系。结论(1)提示大肠癌的发生发展与BAFF、MRP、PD-L2的表达有密切关系。(2)提示大肠癌临床指标与BAFF、MRP、PD-L2的表达关系不密切。
Objective To study the expression and significance of BAFF, MRP and PD-L2 in colorectal cancer. Methods The expression of BAFF, MRP and PD-L2 in colorectal cancer and its relationship with clinical parameters were detected by immunohistochemical S-P method and detection of 60 cases of colorectal cancer tissue and 10 cases of normal colorectal tissue. Results (1) The positive rates of BAFF, MRP and PD-L2 in 60 cases of colorectal cancer were 83.3% (50/60), 41.7% (25/61) and 68.9% (42/61) . In normal colorectal tissues, the positive rates of BAFF, MRP and PD-L2 expression were 20% (1/10), 0% (0/10) and 0% (0/10), respectively. (2) clinical symptoms and the expression of BAFF, MRP, PD-L2 and clinical symptoms. Conclusion (1) suggests that the occurrence and development of colorectal cancer is closely related to the expression of BAFF, MRP and PD-L2. (2) Tip Colorectal cancer clinical indicators and BAFF, MRP, PD-L2 expression is not closely related.