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目的研究灵长类胰岛引流系统与胰腺门脉循环的功能及临床意义。方法用微血管树脂/墨汁灌注扫描电镜/光镜观察、保留动态及组织信息在静态样本的微循环观察法、微循环图象计算机三维重建法 ,对11例男性尸体及40只猴的胰岛血液循环的引流通道及其功能意义进行了系统研究。结果血液经胰岛的入岛动脉 (胰腺小叶内动脉的分支 )到达胰岛血窦 (胰岛毛细血管球 )再经胰岛的输出血管 (出岛门脉 )引流至不同区域的腺泡毛细血管网 ,构成了不同特点的胰腺门脉循环。研究者根据不同区域门脉循环的特征对其进行了分类及命名 :①连续型胰岛 -腺泡门脉循环 :所有灵长类胰岛都具有这类门脉循环。特点是引流系统管径细、行程短、引流至胰岛周围的腺泡毛细血管区域 ;②聚合型胰岛 -腺泡门脉循环 :为部分胰岛所有 ,特点是引流管径粗、行程长 ,引流至远离胰岛的腺泡毛细血管区域 ;③跨越型胰岛 -腺泡门脉循环 :为部分胰岛所有 ,特点是输出管道越过小叶间隔引流至另一胰腺小叶的腺泡毛细血管区域 ,而这一小叶往往没有胰岛存在。结论灵长类胰岛完善的引流系统构成了胰腺内 -外分泌完整的微循环联系 ,即胰岛 -腺泡门脉循环 ;微循环血液流向由内分泌部流向外分泌部 ,提示了胰腺内分泌激素可能是胰腺外分泌腺泡功能活动不可缺少的?
Objective To study the function and clinical significance of primate pancreatic islet drainage system and pancreatic portal circulation. Methods Microvascular resin / ink perfusion scanning electron microscopy / light microscopy observation, retention of dynamic and tissue information in the static sample microcirculation observation, microcirculation computerized three-dimensional reconstruction method, 11 cases of male and 40 monkeys islet blood circulation Drainage channels and their functional significance of a systematic study. Results The blood was transferred to the acinar capillaries in different regions by the islets into the islet artery (branches of the pancreatic lobules arteries) reaching the islet sinusoids (islet capillaries) and then through the islet output vessels (out portal vein) Different characteristics of the pancreatic portal circulation. Researchers based on the characteristics of different regions of the portal circulation of its classification and naming: ① continuous pancreatic islet - acinar portal circulation: all primate islets have such portal circulation. Characteristics of the drainage system is small diameter, short stroke, drainage to the pancreatic islet around the acinar capillary area; ② polymeric islet - acinar portal circulation: part of all islets, characterized by drainage tube diameter, long stroke, drainage to Far from islet capillaries of the insulinoma; ③ leap-type islets - acinar portal circulation: part of the islet all, characterized by the export of pipelines across the interlobular septa drain to the acinar capillary area of another pancreatic lobule, and this leaflet often No islets exist. Conclusion The perfect drainage system of the primate islet constitutes the complete microcirculation of the pancreatic endocrine system, that is, the islet-acinar portal circulation. The microcirculation of blood flow from the endocrine to the exocrine, suggesting that the pancreatic endocrine hormone may be pancreatic exocrine Acinar function indispensable?