论文部分内容阅读
目的:探讨不同类型冠心病患者血清白介素-37(IL-37)的水平及其与血清白介素-6(IL-6)、白介素-10(IL-10)、C反应蛋白(CRP)水平的关系。方法:选取急性心肌梗死患者20例(AMI组)、不稳定性心绞痛患者26例(UAP组)、稳定性心绞痛患者20例(SAP组)及冠脉造影正常者26例(CON组)为研究对象,采用酶联免疫吸附法(ELISA)测定其血清IL-37、IL-6、IL-10和CRP的水平并分析其相关性。结果:1UAP组、AMI组血清IL-37水平均较对照组(CON组)显著增高(p<0.05),而SAP组与CON组比较无明显差异(P>0.05)。2冠心病患者的血清IL-37水平与其血清CRP(r=0.3,P<0.05)、IL-6(r=0.4,P<0.05)水平均存在显著正相关性,与IL-10水平无明显相关(P=0.16)。当排除SAP组患者后,冠心病患者的血清IL-37水平与CRP(r=0.3,P<0.05)、IL-6(r=0.5,P<0.05)、IL-10(r=0.2,P<0.05)水平均显著相关。结论:急性冠脉综合症(ACS)患者的血清IL-37水平显著升高,并与IL-6、IL-10、CRP水平相关,可能参与了ACS发病过程中的炎症反应。
Objective: To investigate the levels of serum interleukin-37 (IL-37) and its relationship with serum interleukin-6 (IL-6), interleukin-10 (IL-10) and C-reactive protein (CRP) in patients with different types of coronary heart disease . Methods: A total of 20 patients (AMI group), 26 patients with unstable angina pectoris (UAP group), 20 patients with stable angina pectoris (SAP group) and 26 patients with normal coronary angiography (CON group) were enrolled in this study The serum levels of IL-37, IL-6, IL-10 and CRP were measured by enzyme linked immunosorbent assay (ELISA) and their correlations were analyzed. Results: Serum levels of IL-37 in 1UAP group and AMI group were significantly higher than those in CON group (p <0.05), while there was no significant difference between SAP group and CON group (P> 0.05). Serum levels of IL-37 in patients with coronary heart disease were positively correlated with serum CRP levels (r = 0.3, P <0.05) and IL-6 levels (r = 0.4, Related (P = 0.16). The levels of IL-37 in patients with coronary heart disease were significantly lower than those in patients with SAP (r = 0.2, P <0.05), IL-6 <0.05) levels were significantly correlated. CONCLUSIONS: Serum IL-37 levels are significantly elevated in patients with acute coronary syndrome (ACS) and are associated with the levels of IL-6, IL-10 and CRP, and may be involved in the inflammatory reaction in the pathogenesis of ACS.