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目的:探讨依达拉奉联合醒脑静注射液防治重型颅脑损伤急性期脑血管痉挛的效果。方法:将格拉斯哥昏迷(GCS)评分6-8分的颅脑损伤患者61例随机分为对照组(n=29)和治疗组(n=32),分别以常规方法和在常规治疗基础上加依达拉奉和醒脑静注射液治疗,以经颅多普勒超声(TCD)为主要评定脑血管痉挛的手段,比较两组患者入院第1、4、7、14 d脑血管痉挛发生率、颅内血管血流速度、外伤性脑梗塞的发生率、脑脊液内皮素-1(ET-1)浓度及GCS变化。结果:入院第1 d两组患者各项指标差异无统计学意义(P>0.05),治疗组第4、7、14 d的各项指标均明显优于对照组(P<0.05)。结论:在常规治疗的基础上加用依达拉奉和醒脑静注射液能较好地防治重型颅脑损伤急性期的脑血管痉挛。
Objective: To investigate the effect of edaravone combined with xingnaojing injection in prevention and treatment of acute cerebral vasospasm in patients with severe traumatic brain injury. Methods: Sixty-one patients with craniocerebral injury who had a GCS score of 6 to 8 were randomly divided into control group (n = 29) and treatment group (n = 32). The patients were divided into two groups according to the conventional method and routine treatment Edaravone and xingnaojing injection, and transcranial Doppler ultrasonography (TCD) as the main measure of cerebral vasospasm. The incidence of cerebral vasospasm on the 1st, 4th, 7th and 14th days after admission was compared between two groups , Intracranial vascular blood flow velocity, the incidence of traumatic cerebral infarction, cerebrospinal fluid endothelin-1 (ET-1) concentration and GCS changes. Results: There was no significant difference between the two groups on the 1st day after admission (P> 0.05). The indexes of the 4th, 7th and 14th day of the treatment group were significantly better than those of the control group (P <0.05). Conclusion: Edaravone and xingnaojing injection can effectively prevent and treat cerebrovascular spasm in the acute stage of severe traumatic brain injury.