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目的:了解新生儿发生毛细血管渗漏综合征(CLS)的相关危险因素。方法:对620例新生儿进行回顾性分析,采用Logistic回归模型分析毛细血管渗漏综合症发生的危险因素。结果:620例新生儿中有168例诊断为CLS,单因素分析显示严重感染、呼吸窘迫综合征、早产、重度窒息、发病前低体温对新生儿CLS的发生有影响(P<0.05),经多元Logistic回归分析显示严重感染、呼吸窘迫综合征、早产是发生CLS的独立危险因素(P<0.05)。结论:严重感染、呼吸窘迫综合征、早产是发生CLS的独立危险因素。
OBJECTIVE: To understand the risk factors associated with capillary leak syndrome (CLS) in newborns. Methods: A retrospective analysis of 620 newborn infants was conducted. Logistic regression analysis was used to analyze the risk factors of capillary leak syndrome. RESULTS: 168 of 620 newborns were diagnosed as CLS. Univariate analysis showed that severe infection, respiratory distress syndrome, premature birth, severe asphyxia and hypothermia before onset had an impact on the incidence of neonatal CLS (P <0.05) Multiple logistic regression analysis showed that severe infection, respiratory distress syndrome and premature labor were independent risk factors of CLS (P <0.05). Conclusion: Severe infection, respiratory distress syndrome and premature labor are independent risk factors of CLS.