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目的对比分析单纯放疗及应用植入性氟尿嘧啶同步放化治疗老年宫颈癌初治患者的疗效和并发症。方法选择2006年11月至2007年5月在吉林省肿瘤医院收治的初治宫颈癌患者共58例,临床分期为Ⅰb-Ⅲb期,按治疗方法不同分为单纯放疗组(共30例,给予X线远距离治疗机体外照射及192Ir腔内后装治疗)和同步放化疗组(共28例,给予宫颈植入氟尿嘧啶缓释剂500~800mg,同时给予X线远距离治疗机体外照射及192Ir腔内后装治疗),对两组患者的疗效及并发症发生情况进行对比分析。结果单纯放疗组与同步放化疗组有效率分别为92%、86%,两组比较,差异有统计学意义(P<0.05)两组患者近期并发症均以骨髓抑制为主,其中Ⅲ级以上骨髓抑发生率分别为3%、0%,两组比较,差异无统计学意义(P>0.05)。结论宫颈植入性化疗协同放疗在不增加患者毒副反应的同时可明显改善老年宫颈癌患者的预后。
Objective To compare and analyze the curative effect and complication of radiotherapy alone and concurrent implantation of 5-fluorouracil in the treatment of newly diagnosed cervical cancer in the elderly. Methods A total of 58 patients with newly diagnosed cervical cancer admitted to Cancer Hospital of Jilin Province from November 2006 to May 2007 were enrolled in this study. The clinical stage was stage Ⅰb-Ⅲb. The patients were divided into radiotherapy group (30 cases in total, X-ray long-range treatment of external body irradiation and 192Ir intracavity afterloading therapy) and concurrent radiotherapy and chemotherapy group (a total of 28 cases, given cervical fluorouracil sustained-release 500 ~ 800mg, while giving long-distance X-ray treatment of external beam and 192Ir Intracavity after-treatment), the two groups of patients with complications and complications were analyzed. Results The effective rates of radiotherapy alone and concurrent radiotherapy and chemotherapy were 92% and 86%, respectively. There was significant difference between the two groups (P <0.05). The recent complication of the two groups were mainly myelosuppression. Myelosuppression rates were 3% and 0%, respectively, with no significant difference between the two groups (P> 0.05). Conclusion Cervical implantable chemotherapy combined with radiotherapy can significantly improve the prognosis of elderly patients with cervical cancer without increasing the side effects of the patients.