论文部分内容阅读
目的:观察大剂量泮托拉唑治疗消化性溃疡合并消化道出血的疗效及安全性。方法:选取本院2010年1月-2015年1月收治的消化性溃疡合并消化道出血患者50例,根据泮托拉唑使用剂量的不同分为大剂量组与小剂量组。大剂量组每次给予泮托拉唑80 mg静滴,2次/d;小剂量组每次给予泮托拉唑40 mg静滴,2次/d。观察两组患者临床疗效及溃疡愈合情况,并对治疗前后血压、肝肾功能指标进行对比分析。结果:大剂量组临床治疗有效率为96.0%,小剂量组临床治疗有效率为76.0%,组间比较,差异具有统计学意义(P<0.05);大剂量组溃疡愈合有效率为92.0%,小剂量组溃疡愈合有效率为72.0%,组间比较,差异具有统计学意义(P<0.05);治疗前后,两组患者收缩压(SBP)、舒张压(DBP)、心率、谷丙转氨酶(ALT)、血肌酐(Scr)等指标比较,差异无统计学意义(P>0.05)。结论:大剂量泮托拉唑治疗消化性溃疡合并消化道出血的临床疗效优于小剂量,并且安全性较高。
Objective: To observe the efficacy and safety of high-dose pantoprazole in the treatment of peptic ulcer complicated with gastrointestinal bleeding. Methods: Fifty patients with peptic ulcer complicated with gastrointestinal bleeding admitted to our hospital from January 2010 to January 2015 were selected and divided into high dose group and low dose group according to the dose of pantoprazole. In the high-dose group, 80 mg of pantoprazole was intravenously administered twice a day, while in the low-dose group, 40 mg of pantoprazole was intravenously administered twice daily. The clinical efficacy and ulcer healing of the two groups were observed, and the blood pressure, liver and kidney function indexes were compared before and after treatment. Results: The effective rate of high-dose group was 96.0%, while that of low-dose group was 76.0%. The difference between the two groups was statistically significant (P <0.05). The effective rate of large-dose ulcer healing was 92.0% The effective rate of ulcer healing was 72.0% in the low-dose group, the difference was statistically significant (P <0.05). Before and after treatment, SBP, DBP, heart rate, alanine aminotransferase ALT), serum creatinine (Scr) and other indicators, the difference was not statistically significant (P> 0.05). Conclusion: The high dose of pantoprazole is superior to low dose in the treatment of peptic ulcer with gastrointestinal bleeding, and its safety is higher.