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甲状腺肿瘤的发生,除了伴随着T3、T4、TSH等内分泌激素的一系列变化外,还与多种细胞因子的作用有着密切关系。本文介绍了表皮生长因子(EGF)、血小板源性生长因子(PDGF)、转化生长因子(TGF-α、TGF-β1)胰岛素样生长因子-1(IGF-1)及其各自受体与甲状腺肿瘤细胞生长的关系,以及各细胞因子之间的相互作用关系。 细胞因子与甲状腺肿瘤的关系 EGF及其受体 EGF与多种组织细胞的生长刺激作用有关,表皮生长因子受体(EGF-R)则是癌基因G-erbB-1的表达产物,它与相应配体EGF结合引起细胞过度分裂与增殖。研究发现,EGF的促甲状腺肿瘤细胞生长作用与EGF及其受体在细胞内的定位有关。在正常甲状腺组织中,EGF/EGF-R存在于甲状腺滤泡上皮细胞胞质中。在Graves’病患者中,EGF/EGF-R胞质染色加深,而核染色阳性则是甲状腺滤泡状癌及腺瘤的特征。在乳头状癌及腺瘤细胞中,EGF/EGF-R核染色为阴性。此外,免疫组化染色显示,在分化性甲状腺癌中,EGF-R阳性表达率达61.2％,其中乳头状癌62.5％,滤泡状癌61％,均高于甲状腺良性癌变(P<0.05)。尤其是伴有淋巴转移的甲状腺癌,其表达率高达83.9％,而无淋巴转移者为48.6%,(P<0.05)。提示EGF/EGF-R
Thyroid neoplasms, in addition to a series of changes associated with endocrine hormones such as T3, T4, TSH, but also with a variety of cytokines are closely related. This article describes the relationship between the expression of epidermal growth factor (EGF), platelet derived growth factor (PDGF), transforming growth factor (TGF-|Â), insulin-like growth factor-1 The relationship between cell growth, and the interaction between various cytokines. Relationship between Cytokines and Thyroid Tumors EGF and its receptor EGF are related to the growth stimulating effect of many kinds of tissue cells. The epidermal growth factor receptor (EGF-R) is the expression product of oncogene G-erbB-1, Ligand EGF binding causes cell division and proliferation. The study found that the role of EGF in the growth of thyroid tumor cells and EGF and its receptors in the intracellular localization. In normal thyroid tissue, EGF / EGF-R is present in the cytoplasm of thyroid follicular epithelial cells. In Graves’ disease, cytoplasmic staining of EGF / EGF-R deepens, whereas positive staining of nuclei is a hallmark of thyroid follicular carcinoma and adenoma. In papillary carcinoma and adenoma cells, EGF / EGF-R nuclear staining was negative. In addition, immunohistochemical staining showed that the positive rate of EGF-R in differentiated thyroid cancer was 61.2%, of which 62.5% were papillary carcinoma and 61% follicular carcinoma, both of which were higher than that of benign thyroid carcinomas (P <0.05) . Especially in thyroid cancer with lymphatic metastasis, the expression rate was as high as 83.9%, but no lymphatic metastasis was 48.6% (P <0.05). Tip EGF / EGF-R