论文部分内容阅读
影晌异菸肼导致的周围神经炎的发生频率的因素异菸肼的剂量:异菸肼常规使用剂量为每日每公斤体重5毫克左右,即每日300毫克,一般不至引起周围神经炎,如有也极为罕见。这已为国内外30年的广泛实践所证实。但随着异菸肼使用剂量的增加,周围神经炎的发生频率也增多。1960年Devadatta等报告采用异菸肼200～300毫克未见周围神经炎的发生,当剂量增至每公斤体重8～10毫克时,有13％发生周围神经炎。1960和1963年马德拉斯结核病化疗中心单用异菸肼治疗肺结核,在一年的治疗期间,采用常规剂量异菸肼(每
Factors affecting the frequency of occurrence of peripheral neuritis caused by isoniazid Isoniazid dose: Isoniazid routinely used at doses of about 5 mg / kg body weight per day, that is, 300 mg daily, generally do not cause peripheral neuritis , If it is also extremely rare. This has been confirmed by 30 years of extensive practice at home and abroad. However, with the dose of isoniazid increased, the incidence of peripheral neuritis has also increased. In 1960, Devadatta et al reported no ischaemia in 200 to 300 milligrams of isoniazid. When the dose was increased to 8 to 10 milligrams per kilogram of body weight, 13% had peripheral neuritis. Tuberculosis was treated with isoniazid in 1960 and 1963 in Madras’s chemotherapy center. During the one-year treatment period, isoniazid