论文部分内容阅读
目的调查成人胃食管反流病(GERD)和反流性食管炎(RE)在门诊病人中的患病率,并探讨其相关的危险因素。方法对2000例门诊就诊的18～80岁病人进行问卷调查。以胸骨后疼痛感、烧心、反酸、反食症状的频率及程度的积分(Sc,最高40分)作为反流的指标,Sc≥12表明存在症状性反流(GER);再抽取一部分反流阳性病人和对照者用胃镜和24hpH监测作精查,根据精查的正确率对普查结果校正后测算出患病率。结果2000例门诊人群中每日有反酸者占0.42%,烧心者占0.31%,反食者占0.22%,胸骨后疼痛者占0.11%。Sc≥12者125例占6.25%,男女比例为1.45∶1;精查正确率为88.90%,据此推测GERD的患病率为5.56%,RE为1.60%。分层分析显示,有反流症状者在肥胖体形、离异、夜班的患者中的患病率较高。反流组伴发胆石症、支气管炎、肝病、打鼾、咽喉炎和耳病者较为多见(P<0.05)。结论GERD为多发病,本地区的发病率接近于国外。年龄(OR1.081)、饱食(OR4.216)、咖啡(OR8.739)、便秘(OR24.893)、肥胖(OR4.767)、劳累(OR2.476)、油腻食物(OR4.646)和吸烟(OR7.336)等因素与反流有密切的关系。
Objective To investigate the prevalence of gastroesophageal reflux disease (GERD) and reflux esophagitis (RE) in outpatients and to explore the related risk factors. Methods A total of 2000 outpatients aged 18 to 80 years were surveyed. The score (Sc, up to 40 points) of the frequency and degree of sternal pain, heartburn, anti-acid and anti-symptomatic symptoms was taken as the index of reflux, and Sc≥12 was used to indicate the presence of symptomatic reflux (GER) Flow-positive patients and controls with endoscopy and 24hpH monitoring for the investigation, according to the accuracy of the precision of the census results after correction of the prevalence. Results In 2000 outpatients, there were 0.42% acid reflux, 0.31% heartburn, 0.22% anti-eater, and 0.11% pain after sternum. 125 cases of Sc≥12 accounted for 6.25%, the ratio of male to female was 1.45:1; the accuracy rate of fine screening was 88.90%, suggesting that the prevalence of GERD was 5.56% and RE was 1.60%. Hierarchical analysis showed that patients with reflux symptoms in obese body shape, divorced, night shift in patients with a higher prevalence. Reflux patients with cholelithiasis, bronchitis, liver disease, snoring, sore throat and ear disease were more common (P <0.05). Conclusions GERD is frequently-occurring and the incidence in this area is close to that of foreign countries. (OR1.081), satiety (OR4.216), coffee (OR8.739), constipation (OR24.893), obesity (OR4.767), exertion (OR2.476), greasy food (OR4.646) And smoking (OR7.336) and other factors and reflux are closely related.