目的　观察全反式维甲酸、马洛替酯对小剂量CCl4 诱导的肝纤维化大鼠治疗作用。方法　对肝脏Ⅰ、Ⅲ、Ⅳ、Ⅴ型胶原及结蛋白 (desmin)进行免疫组化染色和计算机图像分析 ,并用电镜观察肝细胞、Ito细胞超微结构的变化。结果　CCl4 诱导的大鼠肝纤维化可有一定程度的自然恢复。全反式维甲酸能抑制Ito细胞的激活与增殖 ,马洛替酯有减轻炎症反应的作用 ,但效果较秋水仙碱差。结论　全反式维甲酸、马洛替酯有轻微的治疗肝纤维化的作用 Objective To observe the therapeutic effect of all-trans retinoic acid and maloterthidine on low-dose CCl4-induced hepatic fibrosis in rats. Methods Immunohistochemical staining and computer image analysis of liver type Ⅰ, Ⅲ, Ⅳ, Ⅴ collagens and desmin were performed. The ultrastructural changes of hepatocytes and Ito cells were observed by electron microscope. Results CCl4-induced liver fibrosis in rats may have some degree of natural recovery. All-trans retinoic acid can inhibit the activation and proliferation of Ito cells. Malloti ester can reduce the inflammatory reaction, but the effect is worse than colchicine. Conclusion All-trans retinoic acid and malrotinib have a slight effect on the treatment of hepatic fibrosis