在流行病学研究中应用呼吸量测定,不仅提供了对多种媒介物的职业和环境暴露所产生的急慢性作用的客观证据,也提供了有关建立控制水平所必需的暴露—反应关系的数据。在流行病学研究中,按照标准化规程,用乙酰甲胆碱或组胺激发试验测定非特异性气道高反应性(NSBH)是安全的。作为职业性哮喘临床评价的有效工具,在调查处于职业性哮喘危险中的劳动力时,NsBH测定还被用于劳动者的筛选。标准化和质量控制是在本领域成功地应用肺功能测试的关键。 The use of spirometry in epidemiological studies not only provides objective evidence of the acute and chronic effects of occupational and environmental exposures to various vehicles but also provides an indication of the relationship between exposure and response necessary to establish a level of control . In epidemiological studies, it is safe to use non-specific airway hyperresponsiveness (NSBH) with methacholine or histamine challenge tests according to standardized protocols. As an effective tool for clinical evaluation of occupational asthma, the NsBH assay is also used for worker selection when investigating workforce at risk of occupational asthma. Standardization and quality control are the keys to the successful application of pulmonary function tests in this field.