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有人观察和证实长期用抗惊厥药治疗癫痫病人,可发生佝偻病和骨质软化症(1967—1986)。有人指出抗惊药通过诱导肝微粒体酶使维生素D的破坏增加。此提法已被临床和实验所证实。有研究者于1972年首先证明有规律地服用抗惊厥药的癫痫病人,其血液循环中25—羟基胆骨化醇的浓度比进食相同的对照组低。同年又有人证明大鼠和猪给于巴比酮后胆骨化
It has been observed and confirmed that long-term anticonvulsant treatment of epilepsy patients, rickets and osteomalacia may occur (1967-1986). It was pointed out that anticonvulsants increased the destruction of vitamin D by inducing liver microsomal enzymes. This formulation has been clinically and experimentally confirmed. Researchers first demonstrated in 1972 that patients with epilepsy who regularly took anticonvulsants had lower blood 25-hydroxycholecalciferol concentrations than those who consumed the same control group. In the same year it was also demonstrated that rats and pigs were biliaryized after administering pegone