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采用鸭乙型肝炎动物模型观察六月青总皂苷抗鸭乙型肝炎病毒与保护肝细胞的作用,实验结果表明,六月青总皂苷(1.0,2.0 g·kg-1.d-1)和3TC(50 mg·kg-1.d-1)能明显抑制DHBV-DNA复制,抑制ALT,AST和DHBsAg水平,改善肝组织病理学损伤。不同于3TC的是六月青总皂苷在停药后仍能显示有抑制病毒的作用,没有出现反跳现象,提示,六月青总皂苷抗病毒的作用机制有别于3TC。实验结果表明六月青总皂苷具有有效抑制DHBV-DNA和保护肝细胞的作用。
Using duck hepatitis B animal model to observe the anti-duck hepatitis B virus and the protection of hepatocytes, the experimental results show that the total saponins of June (1.0,2.0 g · kg-1.d-1) and 3TC (50 mg · kg-1.d-1) could significantly inhibit the DHBV-DNA replication, inhibit the levels of ALT, AST and DHBsAg, and improve the pathological liver damage. Different from the 3TC is June Jun total saponins in the withdrawal can still show the role of inhibition of the virus, there is no rebound phenomenon, suggesting that the mechanism of action of Junqing total saponin antiviral is different from the 3TC. The experimental results show that the total saponins of Jun. Have the effect of inhibiting DHBV-DNA and protecting liver cells effectively.