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目的探讨脑性瘫痪 ( CP)儿童脑组织内环境变化及其临床意义。方法 CP组 2 7例 ,正常对照组 2 0例 ,分别测脑脊液 ( CSF)气体分析、生化及电解质指标。CP组综合治疗病情好转后再复测。结果 1CP组治疗前 CSF的 p H值及 HCO- 3浓度与正常对照组比较有显著性差异 ( P<0 .0 1)。 2 CP组治疗前后 CSFPO2 比较有显著性差异 ( P<0 .0 1) ;治疗后 p H值、HCO- 3、BE浓度等较治疗前有所改善。 3脑脊液生化、电解质未见显著变化。结论脑瘫儿童存在脑组织缺氧与酸碱平衡失调。脑脊液气体分析可用来判断病情与预后 ,并可作为临床疗效的直接客观指标。
Objective To investigate the changes of brain environment in children with cerebral palsy (CP) and its clinical significance. Methods 27 cases of CP group, 20 cases of normal control group were measured CSF gas analysis, biochemical and electrolyte indicators. CP group comprehensive treatment of the condition improved after retest. Results The level of p H and HCO-3 in CSF of 1CP group before treatment were significantly different from those in control group (P <0.01). There were significant differences in CSFPO2 between the two groups before and after CP treatment (P <0.01). After treatment, the values of p H, HCO-3 and BE were improved compared with before treatment. 3 cerebrospinal fluid biochemical, electrolyte no significant change. Conclusion Children with cerebral palsy have brain dysfunction and acid-base balance imbalance. Cerebrospinal fluid gas analysis can be used to determine the condition and prognosis, and can be used as a direct objective indicator of clinical efficacy.