患者,男性,31岁,精神障碍史20年,1982年在我院诊断为分裂——情感性精神病,使用氯氮平治疗疗效显著。出院后11年一直单用氯氮平,剂量在100～400mg/日之间,病情稳定,恢复工作。1993年6月11日,在维持氯氮平治疗的情况下,突然出现全身肌肉疼痛、强直、出汗,在当地内科治疗无效而于6月18日夜间急诊送入我院。患者童年曾患肝炎,无肾 Patients, men, 31 years old, mental disorder for 20 years, diagnosed in our hospital in 1982 as schizophrenia - emotional psychosis, the use of clozapine treatment of significant effect. Clozapine has been used alone for 11 years after discharge, and the dosage is between 100 and 400 mg / day, with stable condition and recovery. On June 11, 1993, while suffering from clozapine treatment, sudden onset of generalized muscular pain, rigidity and perspiration resulted in an ineffective medical treatment at the local hospital and was delivered to our hospital at a night emergency on June 18. Childhood had hepatitis, no kidney