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目的探讨北京地区不同程度宫颈病变妇女中,37种HPV亚型感染流行情况。方法研究包括1 082例接受阴道镜检查及组织活检的宫颈病变患者和165名常规视野下宫颈正常的健康对照者,所有研究对象检测37种HPV基因型(PCR+膜杂交法),患者分为炎症和组织学异常(CIN 1、CIN 2/3和癌)组。结果宫颈炎妇女37种HPV亚型、高危型HPV的感染率分别为30.58%和19.22%,均显著低于组织学异常妇女(72.51%,χ2=6.763,P=0.009;66.79%,χ2=251.15,P=0.000)。HPV16、52、58、33是组织学异常妇女感染率最高的亚型。宫颈病变患者HR-HPV感染率在30岁~34岁和55岁~79岁年龄段表现出高峰。结论与其他人群相比,北京地区妇女感染HPV基因型不同,应对HR-HPV感染的高峰年龄人群进行密切观察。
Objective To investigate the prevalence of 37 HPV subtypes in women with cervical lesions of varying degrees in Beijing. METHODS: A total of 1 082 cervical lesions patients undergoing colposcopy and biopsy and 165 normal subjects under normal vision were enrolled in this study. All 37 HPV genotypes (PCR + membrane hybridization) were detected in all subjects. The patients were divided into three groups: inflammation And histological abnormalities (CIN 1, CIN 2/3 and cancer) group. Results The infection rates of 37 HPV subtypes and high-risk HPV in cervicitis women were 30.58% and 19.22%, respectively, which were significantly lower than those in patients with histopathology (72.51%, χ2 = 6.763, P = 0.009; 66.79%, χ2 = 251.15 , P = 0.000). HPV16, 52,58,33 is the highest infection rate of abnormal histological subtype of women. HR-HPV infection rate in patients with cervical lesions in 30 years old to 34 years old and 55 years old to 79 years old peaked. Conclusions Compared with other populations, women in Beijing are infected with different genotypes of HPV, and HR-HPV infection should be observed closely at the peak age.