一九八五年正值Hughes等人首先发表从猪脑分离出两个分别由5个氨基酸组成具有吗啡样活性的多肽物质——蛋-脑啡肽(Met-enke-phalin)和亮-脑啡肽(Leuenkephalin)十周年之际。可以说该成就开创了对吗啡样物质和其它多肽(Peptides)研究新的历史时期。这里,我们就近年来吗啡样多肽在结构、分布、受体和作用方面作一扼要回顾。 一般认为,一个多肽往往可能出一个大的、无活性的蛋白质前体而来。在一定条件下、经过一系列酶的作用,这个大的前体才逐步降解为小的、有活性的多肽产物。内源 In 1985, Hughes et al. First published two peptides, the Met-enke-phalin and the Brilliant-brain, which have the morphine-like activity of 5 amino acids respectively. The tenth anniversary of Leuenkephalin. It can be said that this achievement has opened up a new historical period for the study of morphine-like substances and other peptides (Peptides). Here, we make a brief review of the structure, distribution, receptors and functions of morphine-like peptides in recent years. It is generally believed that a polypeptide can often come from a large, inactive protein precursor. Under certain conditions, after a series of enzymes, this large precursor is gradually degraded into small, active peptide products. Endogenous