药源性急性胰腺炎(DAP)是由于用药而诱导产生的一种急性胰腺炎(AP)。近年DAP报道日趋增多,本文对其发病机理及临床特征作一综述。 1 发病机理与药物种类 目前认为,DAP发病的中心环节为药源性损害对胰酶产生激活作用或继发微循环障碍影响胰腺自身保护机制,促使胰腺自身消化。部分药物可有多重致病作用。 Drug-induced acute pancreatitis (DAP) is an acute pancreatitis (AP) induced by medication. In recent years, increasing reports of DAP, this article on its pathogenesis and clinical features are reviewed. 1 pathogenesis and drug types It is currently believed that the central part of the incidence of DAP drug-induced damage to pancreatic enzyme activation or secondary microcirculation affect the pancreatic self-protection mechanism to promote the pancreas to digest itself. Some drugs can have multiple pathogenic effects.