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目的探讨急性心肌梗死(AMI)患者血清B型利钠肽(BNP)水平与AMI患者早期心功能及冠状动脉病变程度之间的关系。方法将2008年1月至12月住院的AMI患者80例按心功能分为KillipⅠ级组、KillipⅡ级组及KillipⅢ、Ⅳ级组,按冠状动脉病变范围分为单支组、多支组,选择同期住院冠状动脉造影正常者30例为对照组。入院后48h内采用ELISA法测定血清BNP浓度。结果 AMI各级心功能患者BNP浓度均高于对照组,且随Killip级别的升高,BNP浓度呈递增,各组间两两比较,差异均有统计学意义(P均<0.01);AMI冠状动脉病变单支组及多支组BNP浓度明显高于对照组,多支组BNP浓度明显高于单支组(P<0.01)。结论 AMI患者血清BNP水平与患者早期心功能和冠状动脉病变程度密切相关。
Objective To investigate the relationship between the serum level of B-type natriuretic peptide (BNP) and the early cardiac function and coronary artery lesion in patients with acute myocardial infarction (AMI). Methods 80 patients with AMI who were hospitalized from January 2008 to December 2008 were divided into KillipⅠgroup, KillipⅡgroup and KillipⅢⅣgroup according to their cardiac function. According to the range of coronary artery disease, 80 cases were divided into single branch group, multiple branch group, The same period hospitalized coronary angiography in 30 cases as control group. Serum BNP concentration was measured by ELISA method within 48 hours after admission. Results BNP levels in patients with AMI at all levels were significantly higher than those in control group, and BNP levels increased with the increase of Killip level (P <0.01) The concentration of BNP in arterial lesions group and multi-vessel group was significantly higher than that in control group, and BNP concentration in multi-vessel group was significantly higher than that in single vessel group (P <0.01). Conclusion The serum level of BNP in patients with AMI is closely related to the early cardiac function and the degree of coronary artery lesion.