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目的探讨早发冠脉三支病变患者血清氧化低密度脂蛋白(ox-LDL)、载脂蛋白B(ApoB)、载脂蛋白A1(ApoA1)及ApoB/A1的特点。方法共选取冠心病(CHD)患者164例,根据冠脉造影结果分为早发冠脉三支病变组96例(观察组),冠脉正常组(对照组)68例,比较两组患者血脂水平、ox-LDL、及ApoA1、ApoB的水平,分析其与早发冠脉三支病变的关系。结果观察组血清ox-LDL、ApoB、ApoB/A1水平高于对照组(P<0.01);而观察组与对照组血清ApoA1水平比较无统计学差异。Logistic回归分析显示,ox-LDL在两组患者中存在统计学差异(P<0.05)。结论血清ox-LDL、ApoB、ApoB/A1水平是早发冠脉三支病变发生的预测因素,其中ox-LDL是预测早发严重冠脉三支病变发生的独立危险因素。
Objective To investigate the changes of serum ox-LDL, ApoB, ApoA1 and ApoB / A1 in three lesions of premature coronary artery. Methods A total of 164 patients with coronary heart disease (CHD) were enrolled and divided into three groups according to coronary angiography: 96 cases in the three lesions of premature coronary artery (observation group) and 68 cases of normal coronary artery (control group) Level, ox-LDL, ApoA1, ApoB levels, and analyze its relationship with the three lesions of premature coronary artery. Results The levels of serum ox-LDL, ApoB and ApoB / A1 in the observation group were higher than those in the control group (P <0.01). There was no significant difference in serum ApoA1 levels between the observation group and the control group. Logistic regression analysis showed that ox-LDL had statistical difference between the two groups (P <0.05). Conclusions The levels of serum ox-LDL, ApoB and ApoB / A1 are predictors of three lesions of premature coronary artery. Among them, ox-LDL is an independent risk factor for predicting the occurrence of three coronary lesions of premature coronary artery.