论文部分内容阅读
目的乙型病毒性肝炎是目前已确认的病毒性肝炎中对人类健康危害最为严重的一种肝炎。方法采用荧光定量PCR技术对122例乙肝血清标志阳性的孕妇及其婴儿血清进行HBV-DNA定量检测,分析母婴血清中含HBV-DNA的数量存在的相关性。结果在41例“大三阳”的孕妇组中,患者的血清中的HBV-DNA所含的数量在6.00-9.90之间,测的的平均值是7.57±1.27,母婴传播率为82.9%;“小三阳”组孕妇65例,血清HBV-DNA含量范围为<2.00-4.71,均值为413±1.64,母婴传播率为52.3%;在14例单一的HBcAb阳性的孕妇组中,患者的血清中含有的HBV-DNA的数量的范围小于2.00-4.71,测的平均值是3.17±1.54,母婴传播率为12.5%,HBV母婴宫内传播率随孕妇血清HBV-DNA含量的增高而增加。结论母婴乙型肝炎病毒宫内传播率与孕妇血清中HBV-DNA含量呈正相关性(r=0.351,p<0.01),当孕妇血清中HBV-DNA含量>6.00时,乙型肝炎病毒母婴宫内传播率显著增加(增加47.5%),提示有效控制患乙肝孕妇血清中HBV-DNA含量,可明显减少宫内母婴乙肝病毒传播率。
Purpose Hepatitis B virus is the most serious hepatitis that has been confirmed to have been most harmful to human health. Methods Quantitative HBV-DNA was detected in 122 sera of HBV-positive pregnant women and their infants by fluorescence quantitative polymerase chain reaction (PCR), and the correlation between HBV-DNA and maternal-fetal serum was analyzed. Results In the group of 41 pregnant women with “Sansheng Yang”, the amount of HBV-DNA in the serum of the patients was between 6.00-9.90 and the mean value was 7.57 ± 1.27. The mother-to-infant transmission rate was 82.9%; “Sanyangang” group of 65 pregnant women, serum HBV-DNA content range of <2.00-4.71, with an average of 413 ± 1.64, mother-to-child transmission rate was 52.3%; 14 single HBcAb-positive pregnant women group , The serum HBV-DNA contained in the patient ranged from 2.00 to 4.71, the average was 3.17 ± 1.54, and the mother-to-infant transmission rate was 12.5% Increased content and increased. Conclusion The intrauterine transmission rate of maternal hepatitis B and hepatitis B virus is positively correlated with HBV-DNA in pregnant women (r = 0.351, p <0.01). When HBV-DNA content of pregnant women> 6.00, Intrauterine transmission rate was significantly increased (47.5% increase), suggesting that the effective control of hepatitis B in pregnant women serum HBV-DNA content can significantly reduce the rate of intrauterine mother-to-infant hepatitis B virus transmission.