于小鼠背部皮肤制成手术切割伤口，实验组外敷成纤维细胞生长因子（ｆｉｂｒｏｂｌａｓｔｇｒｏｗｔｈｆａｃｔｏｒ，ＦＧＦ）溶液（含ＦＧＦ３００μｇ／ｍｌ，肝素１００μｇ／ｍｌ）０．５ｍｌ，对照组敷生理盐水０．５ｍｌ，无菌纱布包扎，每日一次。术后１、３、５、７、１０ｄ观察伤口愈合情况。结果显示，实验组毛细血管和成纤维细胞较对照组明显增生，并提前２～３ｄ达高峰，表明ＦＧＦ强有力地促进肉芽组织增生和伤口愈合。 Surgical wounds were made on the back skin of mice. In the experimental group, 0.5 ml of fibroblast growth factor (FGF) solution (containing FGF 300 μg / ml and heparin 100 μg / ml) Bacterial gauze bandaged once daily. The wounds were observed at 1, 3, 5, 7 and 10 days after operation. The results showed that the experimental group of capillary and fibroblasts significantly proliferated compared with the control group, and peaked 2 ~ 3d, indicating that FGF strongly promote granulation tissue proliferation and wound healing.