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目的:观察辛伐他汀加通心络胶囊对颈动脉粥样硬化血瘀证的血脂、血黏度及颈动脉内膜媒介厚度(IMT)的影响。方法:给予改善生活方式的指导后,采取单盲法给药(门诊病例严格控制干扰因素)。对照组予辛伐他汀20 mg,日1次;治疗组予服辛伐他汀10 mg,日1次,同时口服通心络胶囊3粒,日3次,两组均连续用药3个月为1个疗程。结果:治疗后治疗组与对照组血清总胆固醇(TC),低密度脂蛋白-胆固醇(LDC-C),甘油三酯(TG)均降低及高密度脂蛋白胆固醇(HDL-C)均升高;两组治疗后IMT,Tmax均变薄,Smax均缩小,较治疗前均有明显下降,其差异有显著性(P<0.05)。两组治疗后血液流变学变化指标较治疗前显著降低(均P<0.05);两组治疗后比较,治疗组血液流变学变化指标较对照组降低更明显,其差异具有显著性(P<0.05)。结论:通心络胶囊与辛伐他汀等调脂药合用,具有明显降低血黏度,调节血脂,使颈动脉内膜-中层厚度变薄,颈动脉横切面最大面积缩小作用。
Objective: To observe the effect of simvastatin and Tongtongluo capsule on blood lipid, blood viscosity and carotid intima media thickness (IMT) in patients with carotid atherosclerosis and blood stasis syndrome. Methods: After giving guidance to improve the lifestyle, taking a single blind method (outpatient cases strictly control the interference factors). The control group was given simvastatin 20 mg once a day. The treatment group was given simvastatin 10 mg once a day. At the same time, 3 capsules of Tongxinluo capsule were orally administered 3 times a day for 3 months A course of treatment. Results: After treatment, the levels of total cholesterol (TC), low density lipoprotein-cholesterol (LDC-C), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) After treatment, the IMT and Tmax of both groups became thinner and Smax both decreased, which were significantly lower than those before treatment (P <0.05). The indexes of hemorheology in both groups were significantly lower than those before treatment (all P <0.05). After treatment, the indexes of hemorheology in the treatment group decreased more obviously than those in the control group (P <0.05). CONCLUSION: Tongxinluo capsule combined with lipid-lowering drugs such as simvastatin has the effects of lowering blood viscosity, regulating blood lipid, thinning the intima-media thickness of carotid artery and narrowing the maximum cross-section of carotid artery.