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自1977年8月起,在306例妇女中,口服dl-18-甲基三烯炔诺酮合并dl-15甲基PGF_(2α)阴道薄膜及长效针剂催经止孕,并以单纯前列腺素薄膜及长效针剂33例对照。前组成功率达97.93％。对照组为81.82％。第一次用PG薄膜至绒毛组织排出时间,两组各为13小时及15小时。流产后阴道流血时间在3周以内者各占82.69％及77.27％。18甲基三烯炔诺酮副反应不明显,PG薄膜反应轻微,PG针剂可有腹泻及呕吐,但均能耐受。曾抽查191例的肝功能,服药前正常,服药后SGPT在15.7％患者中有轻度及中度升高,但无临床症状,并在2～8周内复查均恢复正常。流产的机理可能是18甲基三烯炔诺酮对黄体和子宫蜕膜有明显对抗作用,再加上PG,使子宫收缩而达到完全流产的目的。
Since August 1977, 306 women, oral dl-18-methyltrostylethylnadrolone combined with dl-15 methyl PGF_ (2α) vaginal film and long-acting injection of cures through the pregnancy, and simple prostate Su-film and long-acting injection of 33 cases of control. Before the formation of power reached 97.93%. The control group was 81.82%. The first time PG film to villus tissue discharge time, two groups each for 13 hours and 15 hours. Postpartum vaginal bleeding time within 3 weeks each accounted for 82.69% and 77.27%. Side effects of 18 methyl norethindrone is not obvious, PG film slight reaction, PG injection can have diarrhea and vomiting, but can tolerate. A total of 191 liver function tests were performed before taking the drug. SGPT was mildly and moderately elevated in 15.7% of the patients after taking the drug, but no clinical symptoms were found. All patients returned to normal within 2-8 weeks. The mechanism of miscarriage may be 18 methyltronic norethisterone on the corpus luteum and decidua were significantly antagonistic effect, coupled with PG, uterine contraction to achieve the purpose of complete abortion.