Enprofylline 是新型黄嘌呤衍生物,因其仅有很小的腺苷受体拮抗作用,故无茶碱的利尿、增加胃分泌、游离脂肪酸释放及中枢神经系统兴奋等副作用,而有较好的抗炎及舒张支气管作用。本文观察该药不同剂量对哮喘的疗效及副作用。选择206例均为可逆性气道阻塞性疾病,实验中一般不用口服支气管舒张剂,但必要时可吸入基础需要量的β2受体兴奋剂,同时亦可吸入或口服类固醇,吸入色甘酸钠、抗胆碱药和口服抗组织胺药物,也允许在整个试验期持续应用。所有患者先服用安慰剂bid,3～7天,作为基 Enprofylline is a new type of xanthine derivatives, because it has only a small adenosine receptor antagonism, it is no theophylline diuretic, increased gastric secretion, free fatty acid release and central nervous system excitations and other side effects, and have good resistance Inflammation and relaxation of bronchial effects. This article observed the efficacy of different doses of the drug on asthma and side effects. Select 206 cases are reversible airway obstruction disease, the experiment generally do not have oral bronchodilator, but if necessary, may inhalation of basal β2 receptor agonist, inhaled or oral steroids, cromolyn sodium, Anticholinergics and oral antihistamines also allow continuous use throughout the trial. All patients were given placebo bid 3 to 7 days as a base