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采用大白鼠气管注入法及家兔体外肺巨噬细胞培养方法对金属镉与石英联合毒性作用进行了研究。体内外实验表明加尘后早期镉对石英细胞毒性可能有一定的延缓作用,实验组与对照组于加尘后期毒性作用相同;镉在矽肺形成的早期似有一定的延缓作用,染尘后3~9月时两组致肺纤维化作用基本相同。
The toxic effects of cadmium and quartz were studied by tracheal injection in rats and in vitro culture of rabbit pulmonary macrophages. In vitro and in vivo experiments showed that cadmium could delay the cytotoxicity of quartz in the early stage after dusting. The toxicity of the experimental group was the same as that of the control group at the late stage of dusting. Cadmium appeared to be delayed in the early stage of silicosis, ~ September when the two groups caused almost the same role in pulmonary fibrosis.