目的 探讨慢性牙周炎患者在护理中应用知信行护理模式干预的效果。方法 随机将2020年2月至2021年2月于我院治疗的82例慢性牙周炎患者分为观察组和对照组，每组41例。以知信行护理模式干预的患者为观察组，以常规护理模式干预的患者为对照组，比较两组的护理效果。结果 观察组的健康知识认知率（95.24%vs.71.43%）和治疗依从性（97.62%vs.73.81%）明显高于对照组，差异有统计学意义（P＜0.05）；观察组护理后的主观感受指数表现明显比对照组更好，差异有统计学意义（P＜0.001）；观察组（4“,”Objective To discuss the effect of applying the knowledge-based nursing model intervention in the nursing of patients with chronic periodontitis. Methods From February 2020 to February 2021， 82 patients with chronic periodontitis treated in our hospital were divided into observation group and control group， with 41 cases in each group. Zhixinxing nursing intervention was set as the observation group， and routine nursing was set as the control group， and the nursing effect were compared. Results The health knowledge awareness rate (95.24% vs. 71.43%) and treatment compliance (97.62% vs. 73.81%) of the observation group were significantly higher than those of the control group， and the difference was statistically significant (P ＜0.05). The subjective perception index performance of the observation group after nursing was significantly better than that of the control group， and the difference was statistically significant (P ＜0.001). The effective rate of treatment the observation group (40 cases， accounting for 97.56%) patients with chronic periodontitis was significantly higher than that of the control group (33 cases， accounting for 80.49%)， and the difference was statistically significant (P ＜0.05). The anxiety， depression， pain， and sleep quality of the observation group improved compared with the control group， and the difference was statistically significant (P ＜0.05). After nursing， the quality of life of patients in the observation group was better than that of the control group， and the difference was statistically significant (P ＜0.05). Conclusion The application of the knowledge-belief-practice nursing model in the nursing of patients with chronic periodontitis can improve patients\' health knowledge， improve treatment compliance， improve patients\' subjective perception index， increase the overall effectiveness of treatment， and alleviate patients\' unhealthy emotions and pain， improve the overall quality of sleep and quality of life.